Patients with a history of HF at baseline studied in finerenone and GLP1-RA trials have asymptomatic HFrEF (LVEF < 40%) or HFrEF with NYHA class I, HFpEF (LVEF ≥ 50%), or HFmrEF (LVEF 40–49%). This evidence concerns the gene GLP1R and hydrops fetalis.