The AUCs of the seven hub genes, ADAMTS9, ZFP36, SOCS3, GPR4, GADD45B, CDKN1A, and BAG3, were 0.76, 0.78, 0.83, 0.82, 0.81, 0.81, and 0.78, respectively, in SAE (Fig. 4A-G) and were 0.88, 1, 0.92, 0.75, 0.88, 0.88, and 0.92, respectively, in HE (Fig. 4H-N). The gene discussed is GADD45B; the disease is hereditary elliptocytosis.