Compared to individuals carried GJB2 rs3751385 (AA/BB) variant genotypes, individuals carried GJB2 rs3751385 (BB), FAS rs1468063 (AA/BB) and PTPRN2 rs10081191(AA) variant genotypes had higher risk of NIHL (OR = 4.250; 95% CI = 1.984, 9.539; p < 0.001), and individuals carried GJB2 rs3751385 (BB) and FAS rs1468063 (AA/BB) variant genotypes had the highest risk of NIHL (OR = 12.084; 95% CI = 3.923, 46.526; p < 0.001; Table 4). The gene discussed is GJB2; the disease is noise induced hearing loss.