In our study, six SNPs in five genes, including SIK3 rs6589574, FAS rs1468063 and rs2862833, GJB2 rs3751385, PTPRN2 rs10081191 and CDH23 rs2394795, showed significant (p < 0.05) association with NIHL risk. The gene discussed is PTPRN2; the disease is noise induced hearing loss.