Compared to individuals carried GJB2 rs3751385 (AA/BB) variant genotypes, individuals carried GJB2 rs3751385 (BB), FAS rs1468063 (AA/BB) and PTPRN2 rs10081191 (AA) variant genotypes had a 4.250-fold increased NIHL risk (95% CI = 1.984, 9.539), and individuals carried GJB2 rs3751385 (BB) and FAS rs1468063 (AA/BB) variant genotypes had a 12.084-fold increased NIHL risk (95% CI = 3.923, 46.526). The gene discussed is FAS; the disease is noise induced hearing loss.