FAS and noise induced hearing loss: For age ≥ 45, individuals carried GJB2 rs3751385 (AA/AB) and FAS rs1468063 (BB) in variant genotypes had a 3.012-fold increased risk of NIHL (95%CI = 1.389, 6.567; p < 0.05; terminal node 6), individuals with CNE < 95 (dB(A)·years), without PPE and carried GJB2 rs3751385 (AA/AB) and FAS rs1468063 (AA/AB) variant genotypes had a 10.038 -fold increased risk of NIHL (95%CI = 2.770, 47.792; p < 0.05; terminal node 5).