Finally, the variant alleles of CDH23 rs2394795, FAS rs1468063 and rs2862833, GJB2 rs3751385, PTPRN2 rs10081191 and SIK3 rs6589574 showed significantly association with NIHL risk in logistic regression model after adjusting for multiple variables (Table 2). The gene discussed is PTPRN2; the disease is noise induced hearing loss.