Finally, eight SNPs in six genes (CDH23 rs2394795, FAS rs1468063 and rs2862833, GJB2 rs3751385, PTPRN2 rs10081191, SIK3 rs6589574, and STAT3 rs1053023 and rs1053005) were related to NIHL susceptibility in logistic regression model after adjusting for age, year of noise exposure, smoking and drinking status (p < 0.05; Table 1). Here, SIK3 is linked to noise induced hearing loss.