Compared to the reference group (individuals with age < 45 years and carried GJB2 rs3751385 (AA/BB)), individuals carried GJB2 rs3751385 (BB) and PTPRN2 rs10081191 (AA) variant genotypes had the higher risk of NIHL (OR = 7.585; 95%CI = 3.654, 16.443; p < 0.001; terminal node 8), and individuals carried GJB2 rs3751385 (BB) and PTPRN2 rs10081191 (BB/AB) had a 2.483-fold increased risk of NIHL (95% CI = 1.239, 4.998; p < 0.05; terminal node 7). This evidence concerns the gene GJB2 and noise induced hearing loss.