Numerous studies have showed a systemic low-grade chronic inflammatory state in women with PCOS and that the levels of cytokines (interleukin [IL]-6, IL-18, tumour necrosis factor-α [TNF-α]) and acute-phase proteins (high sensitivity C-reactive protein [hs-CRP], heat shock protein 70 [HSP70]) are increased in the peripheral blood [3]. Here, TNF is linked to polycystic ovary syndrome.