MAPT and early-onset autosomal dominant Alzheimer disease: Thus, OL-HSPB8-EVs might be applied in various proteinopathies, where misfolded protein aggregates are associated with microglia-mediated neuroinflammation, including, for example, Alzheimer’s disease featured by extracellular A \documentclass[12pt]{minimal}\usepackage{amsmath}\usepackage{wasysym}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{amsbsy}\usepackage{mathrsfs}\usepackage{upgreek}\setlength{\oddsidemargin}{-69pt}\begin{document}$$\beta$$\end{document}β plaques and intracellular fibrillary tau tangles, and Parkinson’s disease with Lewy bodies.