NTF3 and experimental autoimmune encephalomyelitis: Beutner et al. engineered microglia derived from embryonic stem cells (ESdM) to express therapeutic neurotrophin-3 (NT-3), which transmigrated across the BBB to reach the inflammatory target and promoted the repair of CNS lesions in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis [75].