Therefore, it cannot be ruled out that the sex-dependent effect on survival in GFAP-IL6/Ndufs4 KO mice is due to a greater susceptibility to developing epilepsy, or a greater severity of seizures in GFAP-IL6/Ndufs4 KO female mice compared to GFAP-IL6/Ndufs4 KO male mice and Ndufs4 KO mice. This evidence concerns the gene GFAP and epilepsy.