After preprocessing the raw data, screening DEGs, constructing PPI networks, and identifying hub genes, we obtained the upregulated hub genes in the fracture and PTSD data sets: RBX1, COMMD8, COMMD6, DCUN1D1, DCUN1D5, TCEB1, COPS2, and CUL3. Here, CUL3 is linked to post-traumatic stress disorder.