We found that patients with DLBCL with low serum ApoA1 levels had a higher percentage of male, more B symptoms, higher levels of LDH, poorer performance status, higher percentage of advanced stage, more cases in which there was more than one extranodal site, higher IPI, and a higher percentage of non-GCB subtypes. Here, APOA1 is linked to diffuse large B-cell lymphoma.