Few studies have demonstrated that abnormal lipid characterization is associated with R-CHOP resistance in a mouse model of DLBCL and that serum free fatty acids, high-density lipoproteins (HDL), low-density lipoproteins, and triglycerides are associated with the prognosis of patients with DLBCL [8–12]. Here, DDIT3 is linked to diffuse large B-cell lymphoma.