INS and obesity due to melanocortin 4 receptor deficiency: The altered hormone signaling and increased ROS by obesogens results in all of the metabolic changes noted in obesity—increased insulin secretion, adipocyte differentiation, altered adipocyte size, number, inflammation and function, increased serum lipids, non-alcoholic fatty liver disease (NAFLD), altered microbiome, insulin and leptin resistance, increased food intake, altered resting metabolic rate, and reduced voluntary energy expenditure [18].