As obvious from Fig. 4d and Supplementary Fig. 30, GPX4 activity in Gi-F-CAA (pH 6.5) treated EJ cells was substantially decreased compared with that of other control groups, indicating the enhanced tumor endocytosis and subsequent AEB effect of Gi-F-CAA (pH 6.5) by in vivo self-assembly. The gene discussed is GPX4; the disease is neoplasm.