We found an overlap of 83 genes between proteins with abundance levels that positively correlate with OXR1 (ρ > 0.30, Supplementary Data 12) from the Accelerating Medicines Partnership – Alzheimer’s Disease (AMP-AD) dataset27 and genes affected by age from the Genotype-Tissue Expression (GTEx) project (Fig. 4h and Supplementary Data 13)28,29. This evidence concerns the gene OXR1 and early-onset autosomal dominant Alzheimer disease.