Our results showed that p-ERK1 (f1, 20 = 23.96, P < 0.0001) and p-ERK2 (f1, 20 = 11.49, P < 0.0002) levels showed a significant difference between T2D and T2D + EX (interaction effect). The gene discussed is MAPK3; the disease is type 2 diabetes mellitus.