As shown Fig. 5D, the level of p70S6k was lower in the T2D (T2D effect) (f1, 20 = 110.2, P < 0.0001) and higher in EX (EX effect) (f1, 20 = 110.2, P < 0.0001) compared to CO groups. The gene discussed is RPS6KB1; the disease is type 2 diabetes mellitus.