Of note, ANXA1, ANXA2, GNAS, HSP90AA1, HSP90AB1 and PSMD2, were highly abundant in EVs captured from GBM neurosurgical aspirates and in Pre-OP GBM uEVs here, implicating a potential brain tumour diagnostic utility for TRiC subunits and their interacting partners [3]. This evidence concerns the gene HSP90AA1 and brain neoplasm.