Intriguingly, multiple ribosomal protein subunits were also among the GBM diagnostic proteins (RPS2, RPL18, RPL28, RPL7, RPL6, RPS8, RPL7A, RPL10, RPL13A), all of which were significantly higher in GBM uEVs relative to HC (Fig. 2b). Here, RPL18 is linked to glioblastoma.