Intriguingly, multiple ribosomal protein subunits were also among the GBM diagnostic proteins (RPS2, RPL18, RPL28, RPL7, RPL6, RPS8, RPL7A, RPL10, RPL13A), all of which were significantly higher in GBM uEVs relative to HC (Fig. 2b). Here, RPL6 is linked to glioblastoma.