As it has been reported that activation of B1R is associated with neuroinflammatory processes34–36 related to neurodiseases37,38 and increased secretion of factors related to pro-inflammatory cytokines25–27, it can be deduced that B1R modulated by serping1 may be involved in the inflammatory reactions in Alzheimer’s disease, and PD can be considered to be a neuroinflammatory disorder24. The gene discussed is BDKRB1; the disease is early-onset autosomal dominant Alzheimer disease.