Clinically, MR blockers have also been shown to have strong antihypertensive effects in patients with excessive salt intake or low-renin hypertension [20, 21], and urinary Na excretion has been reported to positively correlate with the antihypertensive effect of the MR blocker spironolactone and eplerenone [20, 22]. The gene discussed is NR3C2; the disease is Hypertension.