TP53 and nasopharyngeal carcinoma: To explore the global effect on signaling pathways and the underlying mechanism of p53-R280T amyloid formation in NPC, transcriptome sequencing was performed for C666-1, C666-1 pretreated with P8 fibrils (C666-1-P8) and C666-1 infected with R280T plus P8 fibrils treatment (C666-1-R280T-P8).