Activation of the Wnt/β-catenin pathway is known to create non-inflammatory tumor microenvironment by (1), enhancing the survival of regulatory T (Treg) cells; and (2), interacting with tumor-associated macrophages (TAMs) through Snail (a Zinc finger protein encoded by Wnt-regulated gene), which can in turn increase β-catenin activity via IL-1β15–17. The gene discussed is SNAI1; the disease is neoplasm.