Recent studies have revealed the critical role of STING in the pathogenesis of a number of autoinflammatory and neurodegenerative diseases, such as STING-associated vasculopathy with onset in infancy (SAVI)11,12, COPA syndrome13–18, Parkinson’s disease19, and amyotrophic lateral sclerosis20,21. Here, STING1 is linked to neurodegenerative disease.