Our results using Pillai’s trace show that glycemic states (normal, borderline, and hyperglycemia) vary significantly with the five inflammatory markers (CRP, WBC, Platelet, NLR, PLR); group effect exhibiting F-ratioHbA1c of 182.27 (p < 0.0001) and F-ratio FBG of 37.249 (p < 0.0001) indicated by Pillai's trace. The gene discussed is CRP; the disease is Hyperglycemia.