TGFBR2 and intrahepatic cholangiocarcinoma: Together, these results demonstrate that mutations in Trp53, Fbxw7, Inppl1, Tgfbr2, and Cul3 accelerate tumor growth in SPC mice, whereas mutations in Cul3 do not enhance ICC growth in nude mice, suggesting a distinct mechanism associated with Cul3-mediated tumor progression.