As UCHL1 is abundantly expressed in the nervous systems13, we tested the tissue-specific effects of UCH deficiency in developing T2D-related symptoms using several GAL4 drivers, including collagen (cg)-GAL4, myocyte enhancer factor 2 (mef2)-GAL4, and embryonic lethal abnormal vision (elav)-GAL4. This evidence concerns the gene UCHL1 and type 2 diabetes mellitus.