Next, we tried to investigate if the HSD-induced diabetic phenotypes could be improved by expressing GSK3BCA or knocking down Snail. The axonal degeneration and loss of leg sensory neurons, reduced escape responses to heat stimuli, and hyperglycemia induced by HSD were all alleviated by the expression of GSK3BCA or Snail RNAi (Supplementary Fig. 9e–h). The gene discussed is CHST3; the disease is Hyperglycemia.