EDN3 and stroke disorder: Wei et al. suggested that Zeb2/Axin2 from bone marrow MSC-derived exosomes could improve post-stroke neurogenesis, neural plasticity, and spatial memory and nerve function, likely via the SOX10, Wnt/β-catenin, and endothelin-3/EDNRB pathways.142 Wang et al. illustrated that miR-126-modified EPC-derived exosomes could alleviate acute brain injury and promote functional recovery after stroke by enhancing neurogenesis.143