The exosomal miR-25-3p from MSCs could alleviate MI by targeting pro-apoptotic proteins and EZH2 in an OGD cardiomyocytes model and left anterior descending artery ligation animal model.269 Similarly, human iPSC-derived exosomes could improve recovery from MI without increasing the frequency of arrhythmogenic complications in a swine model.270 The work conducted by Wen et al. and Santoso et al. focused on the death of cardiomyocytes. The gene discussed is EZH2; the disease is myocardial infarction.