The hallmarks of NDD include, but are not limited to, pathological protein aggregation, synaptic and neuronal network dysfunction, aberrant proteostasis, cytoskeletal abnormalities, altered energy homeostasis, DNA and RNA defects, inflammation, and neuronal cell death.175 AD is the most common form of dementia globally and accounts for 25 million cases.176 Currently, only two classes of drugs are approved for symptomatic AD treatment, including cholinesterase inhibitors and NMDA antagonists. Here, BCHE is linked to Alzheimer disease.