Similar results were obtained using exosomes from iPSC-derived MSCs.325 The work performed by Ding et al. illustrated that umbilical cord MSC-derived exosomes could restore ovarian phenotype and function in a POI mouse model, promote proliferation of CTX-damaged human GCs and oocytes, and alleviate ROS accumulation by delivering exosomal miR-17-5p and targeting its downstream mRNA SIRT7.326 It was further elucidated that miR-17-5p down-regulated PARP1, γH2AX, and XRCC6 expression by inhibiting SIRT7. This evidence concerns the gene SIRT7 and cerebrotendinous xanthomatosis.