Analysis of RNA-seq data from colon cancer (COAD cancer) and non-colon cancer tissues (COAD normal) from the TCGA database and normal colon tissues (Colon-Transverse) from the GTEx database revealed a strong correlation between the expression of E2F2 and FBXO5 (Fig. 3B), suggesting that FBXO5 may be regulated by E2F2. This evidence concerns the gene E2F2 and malignant colon neoplasm.