UMOD and Hypertension: This largely results from recent genetic studies revealing that mutations in the human uromodulin gene (UMOD) leading to intracellular accumulation of mutant proteins cause autosomal dominant tubulointerstitial kidney disease (ADTKD) [11], that specific UMOD variants are associated with incident chronic kidney disease (CKD) [12–14] and hypertension [15, 16], and that UMOD, among multiple genetic loci, shows the strongest association and largest effect on kidney function [17].