On the otherhand, proneural sEVs were high in adhesion G-protein coupled receptorG1 (GPR56), prominin-1 (PROM1), Thy-1 membrane protein (THY1), agrin(AGRN), contactin-1 (CNTN1), protein tweety homologue 1 (TTYH1), tetraspanin-7(TSPAN7), and chondroitin sulfate proteoglycan 4 (CSPG4), furthersuggesting that the proteome of glioblastoma sEVs differ from subtypeto subtype, which contributes to the heterogeneous nature of the disease(Supporting Information Figure S4). Here, ADGRG1 is linked to glioblastoma.