On the otherhand, proneural sEVs were high in adhesion G-protein coupled receptorG1 (GPR56), prominin-1 (PROM1), Thy-1 membrane protein (THY1), agrin(AGRN), contactin-1 (CNTN1), protein tweety homologue 1 (TTYH1), tetraspanin-7(TSPAN7), and chondroitin sulfate proteoglycan 4 (CSPG4), furthersuggesting that the proteome of glioblastoma sEVs differ from subtypeto subtype, which contributes to the heterogeneous nature of the disease(Supporting Information Figure S4). This evidence concerns the gene TTYH1 and glioblastoma.