BRCA2 and cancer: Cancer biology is highly tissue and cell type-specific [14–18] with most driving somatic alterations either occuring in only a small number of cancer types, e.g., KRAS mutations in pancreatic, lung and colorectal cancers [19], or having a functional impact that varies between impacted tissues, e.g., germline BRCA1/BRCA2 mutations that only drive cancer in estrogen-sensitive tissues [20].