TF and cancer: However, the cases where TF and TPAC scores do have a consistent direction of association for a cancer type across all of the Hallmark gene sets, e.g, KLF13, THAP11 and IRF7 for GBM, are consistent with prior findings on TFs whose activity is linked to cancer (KLF13 [42], THAP11 [43], and IRF7 [44]).