The strong association between TPAC scores and cancer prognosis is also illusrated by Fig 7, where stratification of KIRP patients according to the statistical significance of the TPAC score for Hallmark MYC Targets V1 gene set reveals a dramatic difference in PFI (i.e., significant dysregulation of this gene set relative to normal kidney tissue is associated with a much shorter PFI). The gene discussed is MYC; the disease is cancer.