CRP and stroke disorder: Proinflammatory cytokines produced immediately after stroke onset in the brain and their downstream molecules, such as CRP [42,43], are apparently associated with enhanced neurovascular damage and poor clinical courses in the acute phase [3,44]; however, recent basic studies elucidate that these inflammatory molecules are indispensable for post-stroke restoration of blood flow and tissue repair leading to functional recovery [2,3,42,45].