We could not know the baseline (pre-stroke) BT in the patients; however, because endogenous pyrogens, such as the proinflammatory cytokine interleukin-6, are locally produced in ischemic areas [3], the BT elevation in the early days may reflect the extent of locally produced pyrogens or excessive biological response to the pyrogens, even without acute infectious complications. The gene discussed is IL6; the disease is stroke disorder.