Traditional clinical and pathological indicators, such as tumor size, grade, and lymph node involvement, along with the evaluation of specific biomarkers like estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2), have historically played crucial roles in the staging and prognosis of breast cancer (Rakha et al. The gene discussed is ERBB2; the disease is breast carcinoma.