LEP and Hyperglycemia: Biochemical evaluation of all patients showed evidence of chronic inflammation (hs-CRP), abnormal adipokine secretion (decreased adiponectin and increased leptin) (Figure 2E; P < 0.001), presence of IR as assessed by homeostatic model assessment for IR (HOMA-IR) , fasting hyperglycemia, and almost double the level of triglycerides (Table 1) in presence of increased adiposity.