To gain insight into the possible mechanism of TRIM56 in regulating NAFLD, we first performed an integrative analysis of reported TRIM56 interactomics (BioGrid) and transcriptomic profiling in Trim56-HepKO liver tissues, which yielded FASN as the top hit based on integrated score ranking (Figure 4, A–C). This evidence concerns the gene TRIM56 and metabolic dysfunction-associated steatotic liver disease.