It mainly includes 21 hydroxylase deficiency, 11β-hydroxylase deficiency, 17α-hydroxylase/17, 20-lyase deficiency (17OHD) and congenital lipoid adrenal hyperplasia, among which 17OHD accounts for approximately 1%.[1] 17OHD is caused by mutation of the coding gene CYP17A1, which belongs to the member of 17 subfamily of cytochrome P450 superfamily (P450c17). This evidence concerns the gene CYP17A1 and congenital adrenal hyperplasia.