POMC and Hypertension: As a result, the notable feature of patients with 17OHD are low blood levels of cortisol, androgen, estrogen and a compensatory high adrenocorticotropic hormone (ACTH) levels.[5,6] Excessive levels of ACTH stimulate the 11-deoxycorticosterone (DOC) and corticosterone production, which have powerful mineralocorticoid activity, leading to extracellular volume expansion, hypertension, and hypokalemia.[5–7]