M1 macrophages are usually associated with inflammation and tissue destruction, whereas M2 macrophages are involved in tissue repair and fibrosis.[24] Our study reveals that CCR2 positive monocytes are related to a reduced risk of pulmonary fibrosis, possibly indicating a shift towards an M2 phenotype, thereby playing a role in inhibiting the pathological process of pulmonary fibrosis. The gene discussed is CCR2; the disease is pulmonary fibrosis.