Luteolin, primarily found in Arum Ternatum Thunb and Licorice, exerts its anti-Dengue virus effect by interfering with the host Furin protein and its interaction with the viral prM and NS2B proteins.[32] In addition, luteolin also reduces the level of IL-6 released by Peripheral Blood Mononuclear Cells infected with Antibody-Dependent Enhancement of Dengue Virus (ADE-DENV).[33] Luteolin can reduce both the viral viremia levels and the release of inflammatory cytokines associated with Dengue virus infection. The gene discussed is FURIN; the disease is dengue disease.