APOA1 and dengue disease: Blood tests in patients with severe dengue often show low levels of high-density lipoprotein, and lipid raft depletion mediated by ApoA1, a major structural protein of high-density lipoprotein, inhibits DENV from attaching to cell surfaces.[43] The study of Xiao et al[44] indicated that lipid metabolism disorder is a typical clinical feature of dengue virus infection, and the interaction between DENV and lipid metabolism is involved in viral replication and pathogenesis.