In addition, studies have reported that statins and lipid-regulating drugs can play an anti-dengue virus role, indicating that lipid metabolism plays a certain role in viral infection.[45] By querying the pathway on the Kyoto Encyclopedia of Genes and Genomes platform (KEGG, https://www.genome.jp/kegg/), it is known that key targets such as PIK3CA, AKT1, TNF, IL-6, and other targets participate in the pathway of lipid and atherosclerosis. The gene discussed is PIK3CA; the disease is atherosclerosis.