It was found that CXC chemokine ligand 8, Interleukin 1β (IL-1β), NFκB-1, matrix metalloproteinase 9, interleukin 6 (IL-6), TNF, prostaglandin-endoperoxide synthase 2 and signal transducer and activator of transcription 3 (STAT-3) may be the hub genes for SIN to treat DKD (Fig. 8C, D–F). This evidence concerns the gene TNF and diabetic kidney disease.