TP53 and prolymphocytic leukemia: Cytogenetic analysis can reveal abnormal complex karyotypes including losses of 6q, 11q, 13q and 17p-.[1] Molecular assays were used to demonstrate that TP53 mutations and C-MYC overexpression were significantly present in more than half of B-PLL patients.[5] The presence of TP53 mutations is coupled with resistance to chemotherapy and short survival times and is associated with poor prognosis.