Cardiotoxicity of anticancer therapies may result from the “on-target” effects of vascular endothelial growth factor (VEGF) inhibition or “off-target” effects resulting from inhibition of tyrosine kinases.[21] Hypertension appears to be a predisposing factor for aortic dissection, however, it is not an essential factor. The gene discussed is VEGFA; the disease is hypertensive disorder.