In vivo inhibition of SCF/c-Kit signaling impaired primordial follicle growth and development, FF formation in preantral follicles, and the second stage of preovulatory follicle maturation and ovulation.[14] These findings are of great significance in identifying and regulating new pathways or targets for primordial follicle activation and finding new therapeutic approaches for infertility.[15] Presently, the regulatory mechanism of SCF in human follicular development remains unclear. This evidence concerns the gene KITLG and Infertility.