UBA1 and neurodegenerative disease: Additionally, UBA1 participates in ubiquitination and the neural precursor cell expressed developmentally down-regulated protein 8 pathway for protein folding and degradation, among many other biological processes thus implicating it in mitigating the depletion of ubiquitin during stress.[12] UBA1 appears to be an important regulator of cellular protein homeostasis and has been implicated in neurodegenerative diseases and cancers.[13] As it is characterized by multiple functions, heterogeneity in clinical aspects when mutated is anticipated.[11]