In some individuals, α-gal IgE results in a delayed-onset reaction after ingestion of mammalian meat or its products, known as α-gal syndrome (AGS).13,14 Awareness of and testing for AGS appear to be increasing, with more than 90 000 individuals receiving positive test results between 2017 and 2022.15 The most overt symptoms are similar to a typical food allergy, including angioedema, urticaria, and anaphylaxis.16 In contrast, some individuals with elevated α-gal IgE levels may not experience any symptoms and are categorized as sensitized to α-gal. This evidence concerns the gene IGHE and urticaria.