IGHE and osteoarthritis: We hypothesized that there would be (1) relatively high levels of concurrent seropositivity among individuals with Ehrlichia IgG and α-gal IgE given the shared vector, (2) evidence of no association between prior Rickettsia and/or Ehrlichia exposure and reported joint pain or osteoarthritis, and (3) self-reported arthralgias from individuals with detectable α-gal IgE levels.