Although the influence of B-cell biology is less well understood than CD8s in cancer, there is growing interest in the role of B cells in human tumor microenvironments.36–38 The murine B cell-related data are also concordant with recent publications concerning direct effects, of CD73 inhibiting antibodies, on human B-cells.39,40 These mechanistic data align nicely to the enhanced survival rates and tumor growth control profiles in animals dosed with 5FU+OHP+aCD73+aPD-L1. The gene discussed is NT5E; the disease is cancer.