The regulation of genes linked to dendritic cell biology and antigen presentation (MHC II, ITGAE, ITGAX, DCSTAMP, TARM1, CD301) is particularly interesting and consistent with the work of others exploring CD73 inhibition in the context of RTx4 and adenosine pathway blockade in general.3,4 Wennerberg et al. 4 already highlighted the critical role of RTx induced type 1 interferons for reprofiling the tumor microenvironment, particularly with respect to cDC1’s. Here, NT5E is linked to neoplasm.