Among them, high expression of CDKN2A was a predictive risk/protective factor for the overall survival of ACC, COAD, KICH, KIRC, PCPG, PRAD, UCEC and UVM patients (p < 0.05, Fig. 7A, B), was also a prognostic protective factor for overall survival in HNSCC patients. The gene discussed is CDKN2A; the disease is head and neck squamous cell carcinoma.