One of them was the high expression of CDKN2A, which was highly connected with patient overall survival and was a predictive risk/protective factor for the overall survival of ACC, COAD, KICH, KIRC, PCPG, PRAD, UCEC, UVM patients, was also a prognostic protective factor for overall survival in HNSCC patients. This evidence concerns the gene CDKN2A and head and neck squamous cell carcinoma.