SERPINC1 and spondylo-ocular syndrome: International normalized ratio (INR) ≥ 1.3, activated partial thromboplastin time (aPTT) ≥ 40 s, reptilase time ≥ 18.3 s, factor VIII ≤ 80%, antithrombin III ≤ 75%, protein C ≤ 48%, D-dimer ≥ 315 μg/L, bilirubin ≥ 9 μmol/L, and ferritin ≥ 3100 μg/L showed significant associations with the onset of SOS in the univariate analyses.