An increase of D-dimer, bilirubin, and alanine aminotransferase (ALT) as well as a decrease of antithrombin III and protein C were observed in patients with SOS (Jevtić et al. 2011; Lee et al. 1998; Sartori et al. 2012). Here, SERPINC1 is linked to spondylo-ocular syndrome.