TCF4 and Fuchs endothelial corneal dystrophy: FECD has been linked to a triplet repeat expansion in Transcription Factor 4 (TCF4) denoted as CTG18.1 (Wieben et al. 2012), where an expansion over 40 (Mootha et al. 2014; Xing et al. 2014; Kuot et al. 2017; Skorodumova et al. 2018) or 50 repeats (Nanda et al. 2014; Nakano et al. 2015; Foja et al. 2017; Rao et al. 2017; Zarouchlioti et al. 2018; Viberg et al. 2022) is regarded as a major risk factor for developing FECD.