GNRH1 and cancer: The common top-upregulated GSEA-KEGG pathway among clusters 0 and 1 was focal adhesion (Fig. 5f–5g), suggesting interaction with ECM proteins.46 GSEA-KEGG also identified up-regulation in cancer and various signaling pathways (e.g., chemokine, GNRH, and ERBB) in cluster 1, but not in cluster 0 (Fig. 5f–5g).