This sex–APOE4 genotype interaction significantly influences a range of AD-related outcomes (Christensen et al. 2010; Altmann et al. 2014; Kanekiyo et al. 2014; Tao et al. 2018; Duarte-Guterman et al. 2020; Farmer et al. 2021; Polsinelli et al. 2023). Here, APOE is linked to Alzheimer disease.