For example, CSCC patients showed higher activity in the P53 pathway, apoptosis, PI3K-AKT-MTOR-siganling, hypoxia, etc. Furthermore, immune related pathways (interferon-alpha-response, interferon-gamma-response, inflammatory response, IL6-JAK-STAT3-siganaling, complement) were also more active in CSCC patients than in ADC patients. This evidence concerns the gene STAT3 and skin squamous cell carcinoma.