TM4SF1 and neoplasm: TM4SF1 was highly expressed in the majority of tumor types namely, Cholangio carcinoma (CHOL), LIHC, THCA, Esophageal carcinoma (ESCA), and markedly lowly expressed in bladder cancer (BLCA), Kidney renal papillary cell carcinoma (KIRP) (Figure 2A).