Cluster 2 relates to genes involved in kinase signaling pathways: RET (responsible for MEN2 [Multiple endocrine neoplasia type 2]), NF1 (Neurofibromatosis type 1), TMEM127 (Transmembrane protein 127) and MAX (MYC-Associated factor X) and are characterized by high expression of cell membrane norepinephrine and/or LATs, also uniquely positioned in the imaging approach of these tumors. This evidence concerns the gene TMEM127 and multiple endocrine neoplasia.