Infection of androgenized Ksp-Cre × ARf/f and LysM-Cre × ARf/f mice resulted in high-titer cystitis and pyelonephritis 7 dpi, similar to that of androgenized Cre–ARf/f littermate controls (Fig. S3B) and accompanied by a similar influx of neutrophils to the kidney, both as a percentage of CD45+ cells and in absolute number (Fig. S3C and D). Here, CDKN2A is linked to infection.