TOP2A and neoplasm: We examined the effect of TOP2A overexpression on the tumor growth of transplanted SiHa cells with knockdown HPV16 E6, and found that TOP2A overexpression increased the tumor volume and weight of SiHa cells with knockdown HPV16 E6, upregulated the Ki‐67 expression, and decreased the apoptosis rate of transplanted tumor cells (Figure 7A–E).