In the non-diabetic MWF rat model of CKD with GH, we showed a renoprotective effect of combined EP2/EP4 receptor inhibition of the COX2-PGE2-EP2/EP4 axis, since dual receptor blockade during onset of albuminuria development ameliorated albuminuria in this model, while systemic arterial blood pressure and GFR were not affected (Kourpa et al., 2023). This evidence concerns the gene PTGER4 and chronic kidney disease.