However, the activity of PGE2 degrading enzymes and thus the metabolic pathway of COX2-PGE2 have not yet been implicated in renal physiology nor their potential contribution to the initiation and/or progression of CKD, i.e., albuminuria (Nasrallah et al., 2014; Srivastava et al., 2014; Chen et al., 2018). Here, PTGS2 is linked to chronic kidney disease.